Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling.

Dengue virus Type 2 (DENV-2) is predominant serotype causing major dengue epidemics.There are a number of studies carried out to find its effective antiviral, however to date, there is still no molecule either from peptide or small molecules released Phone Accessories as a drug.The present study aims to identify small molecules inhibitor from Natio

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DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells

The Nucleosome Remodeling and Deacetylase (NURD) complex is a key regulator of cell differentiation that has also been implicated in tumorigenesis.Loss of the NURD subunit Deleted in Oral Cancer 1 (DOC1) is associated with human oral squamous cell carcinomas (OSCCs).Here, we show that restoration of DOC1 expression in OSCC Jewelry Box cells leads t

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